Long acting parenteral formulations are preferred over conventional formulations for the
treatment of chronic diseases. Prevalence of such diseases provoked the interest of researchers and
pharmaceutical industries in the development of long acting parenteral formulations. The regulatory
guidelines and pharmacopoeia have remained silent on dissolution methods for long acting parenteral
formulations due to their diverse nature. The lack of compendial method for dissolution testing increases
the duration of approval process for long acting parenteral formulations. This article reviews various dissolution
methods used to study in vitro drug release profile of long acting parenteral formulations. Compendial as well as noncompendial
methods, such as- rotating dialysis cell, dialysis tube, rotating bottle, shaking flask, single drop, inverted cup
and incubation, are used by researchers for drug release profile of long acting parenteral formulations. This review article
also highlights the advantages and disadvantages of reported dissolution methods along with the suitability of these methods
for particular type of long acting formulation. The compiled work will help the researchers in designing the biorelevant
dissolution method and expedite the development of long acting parenteral formulations.
Keywords: Dissolution apparatus, injectable, in vitro models, long acting formulations, parenteral.
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