New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid

Author(s): Adriano Mollica, Roberto Costante, Azzurra Stefanucci, Ettore Novellino

Journal Name: Protein & Peptide Letters

Volume 22 , Issue 8 , 2015

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Graphical Abstract:


Mono or di-substituted prolines, namely proline chimeras of natural or synthetic origin, carry the side chain of other specific amino acids on the pyrrolidine ring. Thus, proline chimeras are useful tools for a wide range of chemical and biological applications as chiral synthons or building blocks for peptidomimetic design. We focused our attention on domoic acid and kainic acid and we report here a concise and up to date review on their stereoselective and asymmetric syntheses.

Keywords: Asymmetric synthesis, building blocks, domoic acid, kainic acid, proline chimeras.

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Article Details

Year: 2015
Published on: 12 July, 2015
Page: [696 - 711]
Pages: 16
DOI: 10.2174/0929866522666150206170716
Price: $65

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