Liposomes as siRNA Delivery Vectors

Author(s): Sabrina Bochicchio, Annalisa Dalmoro, Anna Angela Barba, Gabriele Grassi, Gaetano Lamberti

Journal Name: Current Drug Metabolism

Volume 15 , Issue 9 , 2014

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Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic new agents with limited side effects, potentially useable against a wide range of diseases, including cancer. Among them, the short interfering RNAs (siRNAs), represent very effective molecules. Despite their in vitro efficacy, the major drawback that limits siRNAs usage consists in a difficult delivery due to their very low stability in physiological fluids, and to their limited membrane-permeability through physiological barriers. On the other hand, the liposomes (lipid bilayers closed in vesicles of various sizes) represent interesting drug delivery systems (DDSs) which can be tailored in order to get the best performance in terms of load, vesicle size and transfection yield. In this work, the current state of study in these two fields, and the connections between them, are briefly summarized.

Keywords: Drug delivery, encapsulating methods, liposomes, nucleic acid based drugs (NABDs), polymeric carriers, small interfering RNAs (siRNAs).

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Article Details

Year: 2014
Page: [882 - 892]
Pages: 11
DOI: 10.2174/1389200216666150206124913
Price: $65

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