Male Contraception: Past, Present and Future

Author(s): Christopher Payne, Erwin Goldberg

Journal Name: Current Molecular Pharmacology

Volume 7 , Issue 2 , 2014


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Abstract:

Current contraceptive options available to men include withdrawal, condoms, and vasectomy, each of which has its own drawbacks. In this chapter we will describe the pros and cons for each, as well as methodological and product updates. Statistics from the U.S. Centers for Disease Control on acceptance and satisfaction will be included. Advances in vasectomy and reversal will be presented. Methods to develop new contraceptive technologies fall into two categories: hormonal and non-hormonal. Many targets and strategies have been proposed for non-hormonal male contraception within the testis. Targets include structural components in the testis, as well as enzymes, ion channels and other proteins specific to spermatozoa. Here we provide an overview of the spermatogenic mechanisms and proteins that have received research interest to date. We also discuss potential novel targets, such as ubiquitin specific proteases, that warrant greater research emphasis.

Keywords: Hormonal, male contraception, sperm, targets, testis.

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2014
Published on: 05 February, 2015
Page: [175 - 181]
Pages: 7
DOI: 10.2174/1874467208666150206105636
Price: $65

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