Application of Conventional Heating and Microwave Irradiation for the Biocatalytic Reduction of Fluoroacetophenones by Thermophilic Bacteria

Author(s): Sandra Santos Ribeiro, Suzan Pantaroto de, Patricia Locosque Ramos, João Batista da Cruz, André Luiz Meleiro Porto

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 1 , 2016


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Abstract:

This paper describes the bioreduction of four fluoroacetophenones with thermophilic bacteria (Bacillus sp. FPZSP005, B. subtilis FPZSP088, B. licheniformis FPZSP055 and BC-FPZSP051). The reduction reactions were performed under microwave irradiation and the thermophilic bacteria of the Bacillus genus provided moderate conversions to fluoroalcohols with yields in the 26-42% ranges and 5-62% e.e. When the reactions were carried out under conventional heating, they showed high conversions and selectivities (up to > 99% e.e.). This is the first study in the literature on the use of microwave irradiation with thermophilic bacteria applied on biocatalysis.

Keywords: Bacillus, biocatalysis, bioreduction, microwave irradiation.

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Article Details

VOLUME: 3
ISSUE: 1
Year: 2016
Published on: 30 October, 2015
Page: [9 - 13]
Pages: 5
DOI: 10.2174/2213335602666150205102756

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