Several molecular and genetic studies have provided new perspectives on the histologic classification
of bladder tumors. Recent developments in the field of molecular mutational pathway analyses based on next generation
sequencing technology together with classic data derived from the description of mutations in the FGFR3 (fibroblast
growth factor receptor 3) gene, mutations on TP53 gene, and cDNA technology profiling data gives support to a differentiated
taxonomy of bladder cancer. All these changes are behind the use of non-traditional approach to therapy of
bladder cancer patients and are ready to change our daily practice of uro-oncology. The observed correlation of some molecular
alterations with tumor behavior and the identification of their targets at cellular level might support the use of molecular
changes together with morphological data to develop new clinical and biological strategies to manage patients with
urothelial cancer. The current review provides comprehensive data to support personalized therapy for bladder cancer
based on an integrated approach including pathologic and clinical features and molecular biology.
Keywords: Bladder cancer, genito-urinary cancers, molecular pathology, personalized therapy, precision oncology, targeted therapy.
Rights & PermissionsPrintExport