Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer
death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch
signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated
in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling
plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling
in HCC and its potential therapeutic applications against this cancer.