Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

Author(s): Lichun Sun, Guangchun Sun, Yan Yu, David H. Coy

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 15 , Issue 7 , 2015

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Graphical Abstract:


Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.

Keywords: Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.

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Article Details

Year: 2015
Page: [809 - 815]
Pages: 7
DOI: 10.2174/1871520615666150202102809
Price: $65

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