A convenient green synthesis of benzopyrazines and bis-benzopyrazines has been
performed by the condensation of diversely substituted diamines and dicarbonyl compounds in
water using indium powder as catalyst under controlled microwave exposure. The effects of
microwave power, and temperature on this reaction are investigated in detail to identify the best
condition. A wide range of diversely substituted diamines and dicarbonyl compounds produce
excellent yield of the corresponding benzopyrazines and bis-benzopyrazines. A comparative study
has also been made between microwave-induced procedure and conventional method. The present
method is atom-economical, environmentally friendly, and affords synthetically useful and
challenging products very rapidly.
Keywords: Aqueous, benzopyrazine, green chemistry, indium, microwave, nitrogen heterocycles, quinoxaline.
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