Resveratrol is a phenolic compound that has been widely studied in the last years because of
its extensive pharmacological properties. It also has physicochemical properties that are adequate for
diffusion through the human skin. An analytical method by high performance liquid chromatography
was developed and validated for its determination in transdermal emulsion, as well in receptor media
and skin layers. The trans-resveratrol release kinetic followed the Higushi’s model (R2 = 0.9926) with
steady-state diffusion flux and lag time of 138.5 µg cm–2 h–1 and 0.49 h, respectively. It showed a percentage
at 64.96 % for permeation. Thus, the results suggest that the emulsion studied is a potential vehicle for transresveratrol
administration by transdermal route.
Keywords: Ex vivo human skin permeation, high performance liquid chromatography, in vitro drug release, resveratrol, transdermal
emulsion, validation studies.
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