Studies with Emulsion Containing trans-resveratrol: in vitro Release Profile and ex vivo Human Skin Permeation

Author(s): Priscila Aparecida de Almeida, Michele Campos Alves, Hudson Caetano Polonini, Stephane Lima Calixto, Tiago Brum Braga Gomes, Alexandre Augusto Barros Lataliza, Cristiano Dias da Silveira Ramos, Nadia Rezende Barbosa Raposo, Anderson de Oliveira Ferreira, Marcos Antonio Fernandes Brandao

Journal Name: Current Drug Delivery

Volume 12 , Issue 2 , 2015


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Abstract:

Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validated for its determination in transdermal emulsion, as well in receptor media and skin layers. The trans-resveratrol release kinetic followed the Higushi’s model (R2 = 0.9926) with steady-state diffusion flux and lag time of 138.5 µg cm–2 h–1 and 0.49 h, respectively. It showed a percentage at 64.96 % for permeation. Thus, the results suggest that the emulsion studied is a potential vehicle for transresveratrol administration by transdermal route.

Keywords: Ex vivo human skin permeation, high performance liquid chromatography, in vitro drug release, resveratrol, transdermal emulsion, validation studies.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2015
Published on: 22 April, 2015
Page: [157 - 165]
Pages: 9
DOI: 10.2174/1567201812666150130161736
Price: $65

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