Effect of Environmental Contaminants on Mammalian Testis

Author(s): Faustin P. T. Manfo, Edouard A. Nantia, Premendu P. Mathur

Journal Name: Current Molecular Pharmacology

Volume 7 , Issue 2 , 2014

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Exposure of humans and wildlife to pollutants released in the environment is a centre of attention nowadays. Many of these chemicals (generally referred to as environmental pollutants) have been shown to interfere with normal hormonal signalling and biological functions, leading to reproductive disorders or infertility, which has been a matter of concern within the recent decades. The present paper reviews adverse effects of these toxicants on mammalian testes, with emphasis on alteration of steroidogenesis, spermatogenesis, and histopathological effects. From the publications reviewed, it appears that environmental toxicants, especially heavy metals and organic chemicals of synthetic and microbiological origins, disrupt hormone production and action in the mammalian testes. Endocrine disruption leads to disorders of testicular function and thereby compromises the normal phenotypic development of male sexual characteristics, initiation and maintenance of spermatogenesis. The toxicants also induce impairment of testicular cells function, testicular histology, and sperm cells function directly. The release of the toxicants in the environment is still ongoing, despite alarming quantities that already exist in the atmosphere. If appropriate measures are not taken, their impact on the male reproductive function and especially on testicular function will be more serious.

Keywords: Hormone, mammal, spermatogenesis, testis, toxicity.

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Article Details

Year: 2014
Published on: 26 January, 2015
Page: [119 - 135]
Pages: 17
DOI: 10.2174/1874467208666150126155420
Price: $65

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