T Cell Tuning for Tumour Therapy: Enhancing Effector Function and Memory Potential of Therapeutic T cells

Author(s): Mathias H. Zech, Pedro Velica, Hans J. Stauss

Journal Name: Current Gene Therapy

Volume 15 , Issue 3 , 2015

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer

Abstract:

The genetic engineering of T cells can lead to enhanced immune-mediated tumour destruction and harbors a great potential for the treatment of cancer. Recent efforts have centered on the design of receptors to re-direct the specificity of T cells towards tumour antigens by means of viral gene transfer. This strategy has shown great success in a number of phase one clinical trials. However, there are still challenges to overcome. On the one hand, T cell function can be further improved to optimize the therapeutic outcome. On the other hand, so called safety switches are required to deal with possible on and off target toxicities. In this review, we will give a brief summary of the success and risks of T cell gene therapy before discussing in detail current strategies to enhance effector function, persistence and safety of adoptively transferred T cells.

Keywords: adoptive immunotherapy, cancer, CAR, chimeric antigen receptor, gene therapy, T cells, T cell receptor, tumour immunology.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 15
ISSUE: 3
Year: 2015
Page: [289 - 299]
Pages: 11
DOI: 10.2174/1566523215666150126123037
Price: $65

Article Metrics

PDF: 50
HTML: 3
EPUB: 1