Commentary: The Effects of Psychological Stress on Microglial Cells in the Brain

Author(s): Ti-Fei Yuan, Gonglin Hou, Ying Zhao, Oscar Arias-Carrion

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 14 , Issue 3 , 2015


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Abstract:

Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.

Keywords: Antidepressant, glucocorticoid, microglia, norepinephrine, stress.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2015
Published on: 15 April, 2015
Page: [304 - 308]
Pages: 5
DOI: 10.2174/1871527314666150123122851

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