Psychological stress leads to activation and proliferation of microglial cells
in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including
glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented
the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators
underlying anti-depression therapies.
Keywords: Antidepressant, glucocorticoid, microglia, norepinephrine, stress.
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