Hormone-sensitive breast cancers correspond to breast tumors with the existence of estrogen and progesterone
in the tumor issue. The hormones estrogen and progesterone may in some circumstance promote the
growth of breast cancers. Therefore, compounds targeting hormone-sensitive breast cancers have attracted considerable
interest from synthetic organic chemists. In the past two decades, numerous compounds have thus been designed
and synthesized to investigate their anti-breast cancer activities. In this review, some recent synthetic endeavor
in the past five years towards compounds targeting hormone-sensitive breast cancers, especially estrogenreceptor
positive breast cancers, are summarized.
Keywords: Anti-breast cancer, Estrogen-receptor, ER-positive, hormone-sensitive, MCF-7, stereo-control, synthesis, total synthesis.
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