Title:Anticancer Advances of Matrine and Its Derivatives
VOLUME: 21 ISSUE: 25
Author(s):Jianping Yong, Xiaoyuan Wu and Canzhong Lu
Affiliation:Key Laboratory of Design and Assembly of Functional Nanostructures, Chinese Academy of Sciences of P.R. China, Fuzhou, 350002.
Keywords:Anti-cancer activity, matrine, matrine derivatives.
Abstract:As the second leading cause of death in the world, the total number caused by cancer
in 2008 is 1.4 million. The great cancer incidence worldwide increases the search for new, safer
and efficient anticancer agents (especially to find the new structures and more active anticancer
drugs from the natural products) aiming the prevention or the cure of such illness. For a century,
matrine (an alkaloid isolated from sophorae flavescens Ait.) has been widely studied in the field
of cancer. This review briefly describes the progress of matrine, its derivatives and their anticancer
activity.
