The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction

Author(s): Magdalena Zaniewska, Małgorzata Filip, Edmund Przegalinski

Journal Name: Current Neuropharmacology

Volume 13 , Issue 3 , 2015

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Graphical Abstract:


Although it is generally accepted that the abuse-related effects of amphetamines and cocaine result from the activation of the brain dopaminergic (DA) system, the psychostimulants also alter other neurotransmitter systems. In particular, they increase extracellular levels of norepinephrine (NE) and serotonin by inhibiting respective plasma membrane transporters and/or inducing release. The present review will discuss the preclinical findings on the effects of the NE system modulation (lesions, pharmacological and genetic approaches) on behaviors (locomotor hyperactivity, behavioral sensitization, modification of intracranial self-stimulation, conditioned place preference, drug selfadministration, extinction/reinstatement of drug seeking behavior) related to the psychostimulant addiction.

Keywords: Amphetamine, behavioral sensitization, cocaine, conditioned place preference, drug self-administration, intracranial self-stimulation, locomotor activity, norepinephrine.

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Article Details

Year: 2015
Published on: 21 January, 2015
Page: [407 - 418]
Pages: 12
DOI: 10.2174/1570159X13666150121225659
Price: $65

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