We have constructed a citation network model of the 20% most
cited patent families on cancer and liposomes. This model was structurally
analyzed through a combination of two Cytoscape plugins: Clust&see and
AllegroMCODE. We found four patent meta-families (densely interconnected
regions) in the network model. Three of the four patent meta-families are
related to specific anti-cancer liposomal formulations: LEP-ETU, LE-DT,
Doxil® and Marqibo®. This model was compared with a previous study on the
knowledge translation in literature network. Both models show that liposome
used as a carrier of old drugs is simultaneously the paradigm and the dominant
design for liposomes and cancer. Our results evidence that the innovation
process in this field, is conservative and continuous.
Keywords: Citation network analysis, drug carriers, innovation, patents families.
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