Cardiac hypertrophy can be divided as pathological hypertrophy and physiological hypertrophy.
Unlike pathological hypertrophy, physiological hypertrophy is a beneficial adaptive response, which will
not cause heart failure and sudden death and can protect adverse cardiac remodeling. Exercise training is widely known to
cause physiological hypertrophy. The genomic basis of pathological hypertrophy and heart failure has been well-known
and is well-reviewed. In this review, we will review the genomic profiles of physiological hypertrophy and also summarize
genes and microRNAs responsible for exercise-induced physiological hypertrophy. With better understanding of
physiological hypertrophy, manipulation of genes or miRNAs responsible for physiological hypertrophy will offer exciting
avenues for treating heart failure.
Keywords: Exercise, Physiological hypertrophy, Genomics, MicroRNA
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