Exercise-induced Physiological Hypertrophy: Insights from Genomics

Author(s): Dongchao Lv, Qi Sun, Yuping Deng, Jiahong Xu, Huansen Huang, Junjie Xiao

Journal Name: Current Genomics

Volume 16 , Issue 2 , 2015

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Graphical Abstract:


Cardiac hypertrophy can be divided as pathological hypertrophy and physiological hypertrophy. Unlike pathological hypertrophy, physiological hypertrophy is a beneficial adaptive response, which will not cause heart failure and sudden death and can protect adverse cardiac remodeling. Exercise training is widely known to cause physiological hypertrophy. The genomic basis of pathological hypertrophy and heart failure has been well-known and is well-reviewed. In this review, we will review the genomic profiles of physiological hypertrophy and also summarize genes and microRNAs responsible for exercise-induced physiological hypertrophy. With better understanding of physiological hypertrophy, manipulation of genes or miRNAs responsible for physiological hypertrophy will offer exciting avenues for treating heart failure.

Keywords: Exercise, Physiological hypertrophy, Genomics, MicroRNA

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Article Details

Year: 2015
Published on: 02 March, 2015
Page: [95 - 98]
Pages: 4
DOI: 10.2174/1389202916999150120153618
Price: $65

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