Microwave Assisted Rapid Synthesis of (Arylselanyl)phenyl-1H-1,2,3-triazoles by Copper Catalyzed 1,3-Dipolar Cycloaddition

Author(s): Mauricio C.D.F. Xavier, Daiane M. Xavier, Natália Seus, Eder J. Lenardão, Gelson Perin, Diego Alves

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 1 , 2016

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Graphical Abstract:


We describe here a simple and rapid protocol for the synthesis of (arylselanyl)phenyl-1H- 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions using Microwave Irradiation. The products were obtained under mild conditions in excellent yields in a short reaction time by reacting azidophenyl arylselenides with a range of terminal alkynes using catalytic amount of Cu(OAc)2.H2O/sodium ascorbate. This Click Chemistry protocol is an efficient method to synthesize new selenium compounds with potential application in biological studies and materials sciences.

Keywords: Alkynes, azides, catalysis, 1, 3-dipolar, click chemistry, copper, cycloaddition, green chemistry, heterocycles, microwave, 1, 2, 3-triazoles, nitrogen compounds, selanyltriazoles, selenium compounds.

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Article Details

Year: 2016
Published on: 29 October, 2015
Page: [14 - 23]
Pages: 10
DOI: 10.2174/2213335602666150119221147

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