Proliposomes are phospholipid based drug delivery systems that are finding important applications
in the field of pharmaceutics. Proliposomes have been extensively studied as a potential carrier for oral
delivery of drugs with poor bioavailability, but the mechanism of absorption and cellular uptake pathways
has not yet been clearly understood. An in-depth insight into the physical and biological behavior of
proliposomes is necessary for designing an effective delivery system for enhancing the availability of drug at the intended
site. Reformulation of sub optimal drugs using proliposomes has given an opportunity to improve the therapeutic indices
of various drugs predominantly by altering their uptake mechanism. This work reviews the proliposomal drug delivery
field, summarizes the success of proliposomes for the oral delivery of drugs with poor bioavailability; indicating the key
issues to be addressed to affirm that proliposomes can effectively work as a drug carrier in clinical settings with a clear
understanding of its behavior in biological environment, as they are now an established platform technology with
considerable clinical acceptance.
Keywords: Drug delivery, lymphatic uptake, oral bioavailability, poorly soluble, proliposomes.
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