Natural Compounds Used as Therapies Targeting to Amyotrophic Lateral Sclerosis

Author(s): Seyed F. Nabavi, Maria Daglia, Giuseppe D’Antona, Eduardo Sobarzo-Sanchez, Zeliha S. Talas, Seyed M. Nabavi

Journal Name: Current Pharmaceutical Biotechnology

Volume 16 , Issue 3 , 2015

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Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease that occurs throughout the world with no racial, ethnic or socioeconomic boundaries. Despite its high morbidity and mortality, there are limited medications available for ALS that may increase survival in patients with amyotrophic lateral sclerosis by approximately 2-3 months. Inasmuch as negative effects of riluzole on muscle atrophy and wasting, weakness, muscle spasticity, dysarthria, dysphagia, and overall patient quality of life and its different adverse effects, much attention has been paid to natural products and herbal medicines. Overall scientific reports indicate that natural products have beneficial effects on patients with ALS low side effects and multiple targets. In the present paper, we review the scientific reports on beneficial role of natural polyphenolic compounds in treatment of ALS.

Keywords: Amyotrophic lateral sclerosis, natural substances, polyphenol, oxidative stress.

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Article Details

Year: 2015
Page: [211 - 218]
Pages: 8
DOI: 10.2174/1389201016666150118132224
Price: $65

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