Title:Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents
VOLUME: 3 ISSUE: 1
Author(s):Ashok Sharma, Rajdeep Chowdhury, Subhra Dash, Badvel Pallavi and Paritosh Shukla
Affiliation:Department of Chemistry, Birla Institute of Technology and Science, Pilani Campus, Pilani-333031, Rajasthan, India.
Keywords:Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.
Abstract:A series of compounds having the pyranopyrazole pharmacophore were synthesised by the
traditional method and then by an unreported rapid four-component microwave assisted method. The
microwave strategy required substantially shorter reaction times as compared to the traditional
method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B
cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship
leading to the conclusion that the presence of certain heteroatom substituents at a 3-position
of the pharmacophore may be crucial for anticancer potency.
