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Current Microwave Chemistry

Editor-in-Chief

ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents

Author(s): Ashok Sharma, Rajdeep Chowdhury, Subhra Dash, Badvel Pallavi and Paritosh Shukla

Volume 3, Issue 1, 2016

Page: [78 - 84] Pages: 7

DOI: 10.2174/2213335602666150116233238

Price: $65

Abstract

A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency.

Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.

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