Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents

Author(s): Ashok Sharma, Rajdeep Chowdhury, Subhra Dash, Badvel Pallavi, Paritosh Shukla

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 1 , 2016

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Graphical Abstract:


A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency.

Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.

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Article Details

Year: 2016
Published on: 30 October, 2015
Page: [78 - 84]
Pages: 7
DOI: 10.2174/2213335602666150116233238

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PDF: 82