A series of compounds having the pyranopyrazole pharmacophore were synthesised by the
traditional method and then by an unreported rapid four-component microwave assisted method. The
microwave strategy required substantially shorter reaction times as compared to the traditional
method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B
cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship
leading to the conclusion that the presence of certain heteroatom substituents at a 3-position
of the pharmacophore may be crucial for anticancer potency.
Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.
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