Young Perspectives for Old Diseases

Indexed in: EBSCO

Young Perspectives for Old Diseases is a collaborative monograph describing the current understanding of common neurodegenerative diseases. The monograph focuses on the molecular and cellular ...
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Amyotrophic Lateral Sclerosis: A Role for Non-Neuronal Cells

Pp. 205-222 (18)

DOI: 10.2174/9781608059928115010013

Author(s): Ana G. Barbeito


Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of both upper and lower motor neurons leading to paralysis and finally to death. Non-neuronal cells, including glial cells, have been shown to actively participate in the physiopathological process occurring in ALS. Experiments using chimeric mice expressing ALS-linked mutations suggest that neighboring non-neuronal cells modulate disease phenotype. In this review, recent findings involving the role of astrocytes, microglia and of other non-neuronal cells will be discussed. The study of motor neuron microenvironment could lead to a better understanding of the physiopathology of ALS to find new pathways to slow down motor neuron degeneration.


Amyotrophic lateral sclerosis, ALS, amyotrophia, animal models, astrocytes, CNS, glial cells, microglia, motor neuron, motor neuron disease, neurodegeneration, neuroinflammation, neuroprotection, neurotoxicity, non-cell autonomous, non-neuronal cells, progressive paralysis, SOD1, spinal cord, transgenic mice.