Young Perspectives for Old Diseases

Indexed in: EBSCO

Young Perspectives for Old Diseases is a collaborative monograph describing the current understanding of common neurodegenerative diseases. The monograph focuses on the molecular and cellular ...
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Calcium in Homeostasis and Neurodegeneration

Pp. 85-101 (17)

DOI: 10.2174/9781608059928115010007

Author(s): Flavio H. Beraldo, Ashbell Roy


All brain functions are controlled by specific synapses where the release of neurotransmitters triggers a number of signaling cascades in postsynaptic neurons. One of the most important and common events is a transient and very fast intracellular Ca2+ increase. Intracellular Ca2+ increase is fundamental for modulation of gene expression, neuronal survival and plasticity. In this chapter we will discuss the importance of Ca2+ in cells as well as the regulation of physiological functions in various organisms. Additionally, we will consider mechanisms used by the cells for Ca2+ homeostasis and for increasing intracellular Ca2+ concentration. Finally, the role of Ca2+ in neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington disease (HD) among others will be discussed in this chapter.


Calcium, Alzheimer’s disease, Parkinson’s disease, Cellular signaling, neurodegeneration, neurodegenerative diseases, brain, Inositol Trisphosphate, Endoplasmic Reticulum, Voltage gated Ca2+ channels, glutamate receptors, ATP receptors, Amyotrophic Lateral Sclerosis, Huntington’s Disease, Multiple Sclerosis, SERCA pump, Ligand Ca2+ channels, Calcium Dysregulation, Ca2+-ATPase, Plasma membrane.