DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease

Author(s): Ryan G. Thys, Christine E. Lehman, Levi C. T. Pierce, Yuh-Hwa Wang

Journal Name: Current Genomics

Volume 16 , Issue 1 , 2015

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


DNA has the ability to form a variety of secondary structures that can interfere with normal cellular processes, and many of these structures have been associated with neurological diseases and cancer. Secondary structure-forming sequences are often found at chromosomal fragile sites, which are hotspots for sister chromatid exchange, chromosomal translocations, and deletions. Structures formed at fragile sites can lead to instability by disrupting normal cellular processes such as DNA replication and transcription. The instability caused by disruption of replication and transcription can lead to DNA breakage, resulting in gene rearrangements and deletions that cause disease. In this review, we discuss the role of DNA secondary structure at fragile sites in human disease.

Keywords: Cancer, DNA fragility, DNA secondary structure, Fragile site, Genome instability, Neurological disease.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2015
Published on: 14 January, 2015
Page: [60 - 70]
Pages: 11
DOI: 10.2174/1389202916666150114223205

Article Metrics

PDF: 39