A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease

Author(s): O. Benek, L. Aitken, L. Hroch, K. Kuca, F. Gunn-Moore, K. Musilek

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 9 , 2015

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer
Call for Editor


The amyloid-β peptide (Aβ) has been associated with Alzheimer’s disease (AD) for decades. The original amyloid cascade hypothesis declared that the insoluble extracellular plaques were responsible for Aβ toxicity. Later, this hypothesis has been updated and soluble intracellular Aβ forms and their effects within the cell have come into focus. Mitochondrial dysfunction plays an important role in the pathophysiology of AD. Aβ was detected inside mitochondria and several mitochondrial proteins were found to interact directly with Aβ. Such interactions can affect a protein’s function and cause damage to the mitochondria and finally to the whole cell. This review summarizes the current knowledge of mitochondrial proteins directly interacting with Aβ and discusses their significance for the development of therapeutics in the treatment of AD.

Keywords: Alzheimer‘s disease (AD), amyloid-β peptide (Aβ), drug target, enzyme inhibiton, mitochondria, pharmacotherapy.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2015
Published on: 26 February, 2015
Page: [1056 - 1085]
Pages: 30
DOI: 10.2174/0929867322666150114163051
Price: $65

Article Metrics

PDF: 41
PRC: 1