Owing to its physico-chemical characteristics, the biodegradable and biocompatible polymer
derived from crustacean shells, Chitosan is one of the preferred candidates for green biomedical applications
and also for several industries. Its solubility in acid solutions and ability to form complexes with
anionic macromolecules to yield nanoparticles, microparticles and hydrogels, as well as the ability of chitosan
based nanocomposites to remain stable at physiological pH recommend this polymer for the development
of efficient drug delivery systems. This paper reviews the main utilities of chitosan as a drug delivery component
and describes the most recent technologies which utilize this polymer for developing nanostructured systems with antimicrobial
effect, offering a perspective of using these findings in new, ecological biomedical applications.
Keywords: Antibacterial activity, biocompatibility, chitosan, drug delivery, nanoparticles, wound dressing.
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