From last few years research work on heterocyclic compound and their derivatives has been
increasing. Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active
sites. As a small molecule, it contains electronegative atoms due to which it is feasible for other moieties to
form conjugates. Referring to the bioorganic and medicinal chemistry, the moiety has potential to give active
pharmacophores to develop new therapeutically important compounds. Benzothiazole derivatives were found
to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, neuropathic pain, infectious
diseases, epilepsy etc. In the present review, antiepileptic profile of benzothiazole derivatives is emphasized.
Keywords: Anticonvulsant, antiepileptic, benzothiazole, MES, neurotoxicity, PTZ.
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