Title:Application of Molecular Imaging Technologies in Antitumor Drug Development and Therapy
VOLUME: 21 ISSUE: 16
Author(s):Yan Lin, Zhi-Yi Chen, Feng Yang, Jin-Shan Zhang, Yi-Xiang Wang, Jin-Bing Liu, Jian-Yi Liao, Yang-Ying Liao, Qiu-Lan Zhou, Bing-Cheng Li and Hui-Ying Liang
Affiliation:Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
Keywords:Molecular imaging, drug, therapy, antitumor, development.
Abstract:Molecular imaging enables noninvasive characterization, quantification and visualization of biological
and pathological processes in vivo at cellular and molecular level. It plays an important role in drug discovery and
development. The skillful use of molecular imaging can provide unique insights into disease processes, which
greatly aid in identifications of target. Importantly, molecular imaging is widely applied in the pharmacodynamics
study to provide earlier endpoints during the preclinical drug development process, since it can be applied to monitor
the effects of treatment in vivo with the use of biomarkers. Herein, we reviewed the application of molecular
imaging technologies in antitumor drug development process ranging from identification of targets to evaluation of therapeutic effect.
