Sepsis Pathophysiology and Anesthetic Consideration

Author(s): Koichi Yuki, Naoka Murakami

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
Formerly Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 15 , Issue 1 , 2015

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Graphical Abstract:


Sepsis remains to be a significant health care issue associated with high mortality and healthcare cost, despite the extensive effort to better understand the pathophysiology of the sepsis. Recently updated clinical guideline for severe sepsis and septic shock, “Surviving Sepsis Campaign 2012”, emphasizes the importance of early goal-directed therapy, which can be implemented in intraoperative management of sepsis patients. Herein, we review the updates of current guideline and discuss its application to anesthesic management. Furthermore, we review the recent advance in knowledge of sepsis pathophysiology, focusing on immune modulation, which may lead to new clinical therapeutic approach to sepsis.

Keywords: Anesthetics, early goal-directed therapy, intraoperative, sepsis.

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Article Details

Year: 2015
Published on: 07 January, 2015
Page: [57 - 69]
Pages: 13
DOI: 10.2174/1871529X15666150108114810
Price: $65

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