Regioselective Nitration of Phenols and Phenyl Ethers Using Aluminium Nitrate on Silica as a Nitrating System

Author(s): Mahadeo R. Patil, Pravinkumar H. Mohite, Suresh Shisodia, Rangappa S. Keri

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 2 , 2015

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Abstract:

Silica supported aluminum nitrate (Al(NO3)3·9H2O) was found to be an excellent reagent for the nitration of phenols and phenyl ethers. This procedure works efficiently on most of the examples at room temperature yielding nitro derivatives in fair to good yields with high regioselectivity. The present methodology evidenced a considerable enhancement in the reaction rate along with high o-selectivity, excellent yields, ease of handling and the simplicity in work up.

Keywords: Phenol, nitration, regioselective, aluminum nitrate, silica.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2015
Page: [129 - 135]
Pages: 7
DOI: 10.2174/1570178612666150108000402
Price: $65

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