Natural and Semi synthetic Antimalarial Compounds: Emphasis on the Terpene Class

Author(s): G.N.S. Silva, L.C.D. Rezende, F.S. Emery, G. Gosmann, S.C.B. Gnoatto

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 10 , 2015


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Abstract:

Malaria is one of the most important tropical diseases since more than 40% of the world population is at risk. This disease is endemic to more than 100 nations and remains one of the main leading causes of death in children less than five years of age worldwide. Natural product-derived compounds have played a major role in drug discovery, often as prototypes to obtain more active semi synthetic derivatives. Antimalarial pharmacotherapy is a significant example of plant-derived medicines, such as quinine and artemisinin. This review highlights studies on terpenes and their semi synthetic derivatives from natural sources with antimalarial activity reported in the literature during eleven years (2002-2013). A total of 114 compounds are found among terpenes and their semi synthetic derivatives. Cytotoxicity of the compounds is also found in this review. Furthermore, the physicochemical properties of the terpenes addressed are discussed based on seven well established descriptors, which provide a useful source for the elaboration of a terpene library of antimalarial compounds.

Keywords: Antimalarial, cytotoxicity, drug likeness, malaria, semi synthesis, terpenes.

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Article Details

VOLUME: 15
ISSUE: 10
Year: 2015
Published on: 18 June, 2015
Page: [809 - 836]
Pages: 28
DOI: 10.2174/1389557515666150101101519
Price: $65

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