The derivatives of quinolinone and triazole exhibit antitumor, antiplatelet, antidepressant, and anticonvulsant
properties in diverse experimental systems. In the past decades, we have developed increasingly potent anticonvulsant
agents by the structural modification of compounds derived from 3,4-DHQLO, triazole, and their analogs. Herein, we
report the design and synthesis of a new series of 3,4-DHQLO and triazole and their derivatives; their anticonvulsant
activity was evaluated. Moreover, we also reviewed the anticonvulsant activity of 3,4-DHQLO and triazole and their
derivatives and new approaches.