Immunomodulatory Effects of Endogenous and Synthetic Peptides Activating Opioid Receptors

Author(s): Dorota K. Pomorska, Katarzyna Gach, Anna Janecka

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 14 , Issue 14 , 2014

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The main role of endogenous opioid peptides is the modulation of pain. Opioid peptides exert their analgesic activity by binding to the opioid receptors distributed widely in the central nervous system (CNS). However, opioid receptors are also found on tissues and organs outside the CNS, including the cells of the immune system, indicating that opioids are capable of exerting additional effects in periphery. Morphine, which is a gold standard in the treatment of chronic pain, is well-known for its immunosuppressive effects. Much less is known about the immunomodulatory effects exerted by endogenous (enkephalins, endorphins, dynorphins and endomorphins) and synthetic peptides activating opioid receptors. In this review we tried to summarize opioid peptide-mediated modulation of immune cell functions which can be stimulatory as well as inhibitory.

Keywords: Endogenous opioid peptides, immune system, immunomodulation, morphine, opioid receptors, synthetic opioid peptides.

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Article Details

Year: 2014
Published on: 16 February, 2015
Page: [1148 - 1155]
Pages: 8
DOI: 10.2174/1389557515666150101095237
Price: $65

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