Treatment of osteoporosis remains a therapeutic challenge. The effect of Apium Nodiflorum extract
on development of experimental osteoporosis, pain thresholds and carrageenan-induced inflammation
has been studied in ovariectomized osteoporotic Wistar rats. After osteoporosis verification rats were randomized and received
vehicle only, HPLC-standardized Apium extract (equal to 2.4 mg/kg Quercetin) or Genistein (2.5 mg/kg) for 8
weeks. To verify the effect of Apium on the development of osteoporosis, bone mineral density (BMD) and bone mineral
content (BMC), bone histology and plasma levels of IL-6 and RANKL were measured 6 months after ovariectomy and 8
weeks after treatment with Apium extract or Genistein as comparator. Inflammatory hyperalgesia was induced by intraplantar
injection of 1% Carrageenan. Apium extract and Genistein impeded the development of osteoporosis (significant
differences were shown for BMC and BMD levels in drug vs. vehicle treated rats) and improved bone histology and histological
score. Apium and Genistein decreased IL-6 level. Both treatments alleviated mechanical hyperalgesia, decreased
exudative reaction and lowered inflammatory pain threshold. The results suggested that Apium extract could be an alternative
therapy for post-menopausal osteoporosis.
Keywords: Apium, genistein, inflammatory hyperalgesia, osteoporosis, pain thresholds.
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