Novel One-Pot Synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8- tetrahydroquinazoline-2,5-diones Using Pyridinium p-toluenesufonate as Catalyst

Author(s): Imene Amine Khodja, Raouf Boulcina, Abdelmadjid Debache

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 2 , 2015

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Abstract:

A mild, simple and efficient procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8- tetrahydroquinazoline-2,5-diones is described using pyridinium p-toluenesufonate as an efficient catalyst under mild conditions. Simple methodologies, easy work-up procedure, excellent yields and very short reaction times are among the other advantages of this work.

Keywords: 3, 4, 7, 8-tetrahydroquinazoline-2, 5-diones, 3, 4-Dihydropyrimidin-2(1H)-ones, biginelli reaction, pyridinium-ptoluenesufonate.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2015
Page: [77 - 84]
Pages: 8
DOI: 10.2174/1570178612666141226193727
Price: $65

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