Current Status of Gene Therapy for Hepatocellular Carcinoma, with a Focus on Gene Delivery Approaches

Author(s): Xiaoyu Wang, Zongguang Tai, Wei Zhang, Shen Gao

Journal Name: Current Gene Therapy

Volume 15 , Issue 2 , 2015


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Abstract:

Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality rates, especially in East Asia. Gene therapy is a potential approach for treating HCC. An efficient and safe gene delivery method is a crucial factor for HCC gene therapy. In recent years, gene delivery systems, including viral and non-viral gene vectors, bacteria, and physical methods, have undergone substantial development. Among them, various non-viral vectors have been studied widely and in detail because they are relatively safe and have a high capacity. In this review, we focus on current and emerging HCC delivery techniques and address the challenges involved in the use and improvement of non-viral vectors.

Keywords: Gene therapy, hepatocellular carcinoma, non-viral vector, physical methods, viral vectors.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2015
Published on: 08 March, 2015
Page: [120 - 141]
Pages: 22
DOI: 10.2174/1566523214666141224095411

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