Pathophysiology of Atherosclerotic Plaque Development

Author(s): Andrea Rognoni, Chiara Cavallino, Alessia Veia, Sara Bacchini, Roberta Rosso, Manuela Facchini, Gioel G. Secco, Alessandro Lupi, Federico Nardi, Francesco Rametta, Angelo S. Bongo

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 13 , Issue 1 , 2015

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Cardiovascular diseases and in particular coronary atherosclerotic disease are the leading cause of mortality and morbidity in the industrialized countries. Coronary atherosclerosis has been recognized for over a century and it was the subject of various studies. Pathophysiological studies have unravelled the interactions of molecular and cellular elements involved in atherogenesis; during the last decades the basic research has focused on the study of the instability of atherosclerotic plaque. Plaque rupture and resulting intracoronary thrombosis are thought to account for most acute coronary syndromes including ST – segment elevation myocardial infarction and non ST – segment elevation myocardial infarction. This is a brief review of the pathophysiology of atherosclerotic plaque development.

Keywords: Acute coronary syndromes, atherosclerosis, medical therapy, stable plaque, vulnerable plaque.

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Article Details

Year: 2015
Published on: 18 December, 2014
Page: [10 - 13]
Pages: 4
DOI: 10.2174/1871525713666141218163425

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