Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with
poor prognosis. Most of the HCC patients died quickly because of the rapid tumor progression with no effective
therapy except for liver resection or transplantation. Recently, microRNAs (miRNAs) have emerged as key factors
involved in a series of biological processes ranging from embryogenesis to programmed cell death with aberrant
expression profiles, potentially attractive diagnosis, prognosis or therapeutic applications for related-diseases.
Accumulating evidences have indicated the roles of miRNAs as tumor suppressor in hepatocyte malignant transformation including
development, differentiation, proliferation and tumorigenesis. This article reviews that the recent progress underlies the development of
novel miRNA-based HCC therapeutic strategies in the coming future.