Insulin Resistance, Non-alcoholic Fatty Liver Disease and Hepatitis C Virus Infection

Author(s): Nicolas Goossens, Francesco Negro

Journal Name: Reviews on Recent Clinical Trials

Volume 9 , Issue 3 , 2014

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Graphical Abstract:


Due to their high prevalence, non-alcoholic fatty liver disease (NAFLD), insulin resistance (IR) and hepatitis C virus (HCV) infection are bound to cohabit. However, the relationship between these 3 entities is complex and multilayered. HCV, particularly genotype 3, may induce a “viral” steatosis, morphologically indistinguishable from the steatosis of NAFLD but with different implications and prognosis. On the other hand, epidemiological and experimental data show that patients with HCV have a higher risk of developing IR and, in susceptible individuals, type 2 diabetes (T2D). In patients with HCV, T2D increases fibrosis progression rate, increases the incidence of HCC, worsens liver-related outcomes and worsens response to interferon-α based therapy. We conclude by discussing a possible increased incidence of cardiovascular events in HCV patients.

Keywords: Fibrosis, hepatitis C virus, non-alcoholic fatty liver disease, steatosis.

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Article Details

Year: 2014
Page: [204 - 209]
Pages: 6
DOI: 10.2174/1574887109666141216101939
Price: $65

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PDF: 31