Non-alcoholic fatty liver disease (NAFLD) is extremely prevalent in the Western world. Non-invasive diagnostic
methods should be able to reflect the presence and severity of liver fatty changes and the presence and severity of hepatic
inflammation and fibrosis (features of non-alcoholic steato-hepatitis), since these are related to the risk of progression
and clinical complications.
This article will: a) review the rational basis for the use of ultrasound and transient elastography in patients with NAFLD;
b) summarize available data regarding the diagnostic performance of these two widely used non-invasive imaging methods
in patients with NAFLD; and c) give an overview of newer sonographic applications that might be used in clinical
practice in the near future in this field.
Keywords: ARFI, cirrhosis, controlled attenuation parameter, liver fibrosis, NASH, sonography.
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