Microwave Irradiation As a Substitute for Phase Transfer Catalyst in CAlkylation Reactions

Author(s): Gyorgy Keglevich, Alajos Grun

Journal Name: Current Green Chemistry

Volume 2 , Issue 3 , 2015


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Abstract:

In this minireview, the possible utilization of the microwave (MW) technique in solid–liquid (S–L) phase C-alkylations is summarized. In the S–L phase C-alkylation of a series of simple active methylene containing compounds, such as diethyl malonate, ethyl acetoacetate and ethyl cyanoacetate, as well as P=O-containing derivatives, such as tetraethyl methylenebisphosphonate, diethyl cyanomethylphosphonate and diethyl ethoxycarbonylmethylphosphonate, in most of the cases, there is no need to use a phase transfer catalyst, as MW promotes the reaction in itself. Most of the Calkylations was performed under solvent-free conditions. The elimination of the catalyst and solvent from the system means an environmentally friendly (“green”) accomplishment.

Keywords: C-alkylation, CH-acidic compounds, green chemistry, microwave irradiation, phase transfer catalysis.

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2015
Page: [254 - 263]
Pages: 10
DOI: 10.2174/2213346102666141215212108

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