Targeting ENaC as a Molecular Suspect in Cystic Fibrosis

Author(s): Nadine Bangel-Ruland, Katja Tomczak, Wolf-Michael Weber

Journal Name: Current Drug Targets

Volume 16 , Issue 9 , 2015

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Graphical Abstract:


Cystic fibrosis (CF) is the most common life shortening autosomal inherited disorder, affecting 1 in 2500 newborns in the Caucasian population. In CF the lung pathology is associated with dehydration of the airways epithelial surface which in part results from Na+ hyperabsorption via the epithelial sodium channel (ENaC). The molecular mechanisms of this Na+ hyperabsorption and its correlation with the underlying genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR) are not fully understood. However, it is obvious that a reduced Cl- secretion by CFTR and an enhanced Na+ absorption through ENaC lead to the so far incurable disease. Therefore, it could be indicated to pursue a double-tracked strategy in that way enabling Cl- secretion by a reconstitution of the defect CFTR as well as blocking ENaC to prevent Na+ hyperabsorption. Since the cloning of CFTR great efforts have been done in delivery of CFTR for the correction of the reduced Cl- secretion. Positive benefits for the inhibition of the CF related Na+ hyperabsorption offer technologies using small molecule inhibitors like ASOs or siRNA, which target translation and knockdown of ENaC, respectively. In this review we discuss possible CFTR/ENaC interactions in the context of CF, describe ENaC structure as well as some of the numerous attempts that were performed to prevent the Na+ hyperabsorption in CF related lung disease. Thus, we give a short summary of e.g. amiloride therapy approaches and focus on inventive blocking efforts using ASOs and siRNA.

Keywords: Amiloride, ASOs, cystic fibrosis, CFTR, ENaC, siRNA.

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Article Details

Year: 2015
Published on: 11 December, 2014
Page: [951 - 957]
Pages: 7
DOI: 10.2174/1389450116666141212101626
Price: $65

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