The Simira genus belongs to the Rubiaceae family. Studies of this genus have attracted interest,
mainly due to phototoxic activities, antifebrile, tonic and purgative presented by some secondary metabolites
isolated from drug value of species of this genus. This study is a review of the Simira genus, through the
acquisition of data from studies of phytochemicals and evaluation of biological activities of the species that
compose it, in order to contribute their chemotaxonomic classification within the family.
Keywords: Biological activities, chemical constituents, chemotaxom, phytochemicals, Rubiaceae, Simira.
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