Nandrolone is included in the class II of anabolic androgenic steroids (AAS) which is
composed of 19-nor-testosterone-derivates. In general, AAS is a broad and rapidly increasing group
of synthetic androgens used both clinically and illicitly. AAS in general and nandrolone decanoate
(ND) in particular have been associated with several behavioral disorders. The purpose of this review
is to summarize the literature concerning studies dealing with ND exposure on animal models, mostly
rats that mimic human abuse systems (i.e. supraphysiological doses). We have focused in particular
on researches that have investigated how ND alters the function and expression of neuronal signaling molecules that
underlie behavior, anxiety, aggression, learning and memory, reproductive behaviors, locomotion and reward.
Keywords: Nandrolone decanoate (ND), Anabolic androgenic steroids (AAS), neurological effects, anxiety, aggression,
learning and memory.
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