P2X Receptors and Inflammation

Author(s): Francesco Di Virgilio

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 7 , 2015

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Until recently, P2X receptors have not received much attention in the context of immunology and inflammation. While this is justified to a certain extent for P2X1, P2X2, P2X3, P2X5 and P2X6, which still await identification of a convincing role in the pathophysiology of immune cells, it is clearly not any more the case for P2X4 and even more so for P2X7, a molecule that has achieved the status of an essential, nonredundant, immunomodulatory receptor. In this review I will highlight the most important inflammatory responses participated by P2X receptors.

Keywords: extracellular ATP, innate immunity, P2X4, P2X7, purinergic receptors.

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Article Details

Year: 2015
Published on: 02 February, 2015
Page: [866 - 877]
Pages: 12
DOI: 10.2174/0929867322666141210155311
Price: $65

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