Emerging Potential of Citrus Flavanones as an Antioxidant in Diabetes and its Complications

Author(s): Malvika Sharma, Nadeem Akhtar, Kumar Sambhav, Ganesh Shete, Arvind K. Bansal, Shyam S. Sharma

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 2 , 2015

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Graphical Abstract:


A proper balance between oxidants and antioxidants is necessary in maintaining health and longevity. Alterations in this balance may result in oxidative stress causing functional disorders and diseases. Oxidative stress is considered to play a vital role in the pathogenesis of diabetes and its complications. Flavanones and flavanones-rich botanical extracts have been a subject of great interest for scientific research. Citrus flavanones like naringin and hesperidin exert a variety of biological activities such as anti-oxidant, anti-inflammatory, antihyperglycemic, anti-apoptotic etc. Naringin and hesperidin along with their respective aglycones, naringenin and hesperetin have been shown to attenuate diabetes and its related complications. This review discusses the role of flavanones as a possible emerging treatment for diabetes and its complications along with the possible mechanistic explanations.

Keywords: Diabetes, Diabetic neuropathy, Diabetic cardiomyopathy, Diabetic retinopathy, Citrus flavanones, Oxidative stress, Anti-oxidant.

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Article Details

Year: 2015
Published on: 09 December, 2014
Page: [187 - 195]
Pages: 9
DOI: 10.2174/1568026615666141209163013
Price: $65

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