Title:Preparation and Evaluation of Multi Particulates Drug Delivery System Using Natural Polymers
VOLUME: 12 ISSUE: 3
Author(s):Tariq Baig, Hammad Sheikh, Ankur Srivastava, Pushpendra K. Tripathi and Shalini Tripathi
Affiliation:Department of Pharmacy, Rameshwaram Institute of Technology & Managaement, NH-24 Govindpuram, Sitapur road Lucknow, Uttar Pradesh, India.
Keywords:Drug release, microspheres, simvastatin, sodium alginate.
Abstract:Simvastatin potassium is a hypolipidemic drug used with exercise, diet, and weight-loss to
control elevated cholesterol, or hypercholesterolemia. It is a member of the statin class of pharmaceuticals.
Okra mucilage is used to reduce the cholesterol level since microspheres has formulated by using
okra mucilage to developed a synergistic effect. Calcium chloride act as a cross linking agent,
when react with sodium alginate form a calcium alginate, since develope a gel like microbeads (microspheres).
The half life of simvastatin is 2h for simvastatin acid. Simvastatin microspheres were prepared
by using sodium alginate in combination with Abelmoschus esculentus (Okra), as drug release
modifiers in various proportions to overcome the drug related adverse effects. The drug entrapment efficiency increased
progressively with increasing concentration of both sodium alginate and okra mucilage resulting in the formation of larger
microspheres entrapping greater amounts of the drug. The prepared microspheres were subjected to various evaluation and
in vitro release studies. The particle sizes of the prepared microspheres were determined by optical microscopy and Scanning
Electron Microscopy (SEM) analysis. The prepared microspheres had good spherical geometry with smooth surface
as evidence by SEM. Study the capability of the formulation to withstand the physiological environment of the stomach
and small intestine.
