The chemical versatility of the indole nucleus still inspires the pharmaceutical research to
develop innovative suitable indole based drugs. The present work is an overview of the use and application
of indole molecule based derivatives, as possible treatment in the main Oxidative Stress related
diseases, such as cardiovascular, neurological, and cancer. The indole nucleus is a particular class of
reducers, very efficient when bearing aliphatic substitutions in position 3, like that found in tryptophan
(Trp). The principal chemical modifications carried out on the indole nucleus, were focused to obtain orally active
drugs for a simpler delivery to the patients.
Keywords: Alzheimer, Antioxidants, Cancer, Cardiovascular diseases, Enzymes, Reactive oxygen species.
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