Chromones and their Derivatives as Radical Scavengers: A Remedy for Cell Impairment

Author(s): Preeti Yadav, Badri Parshad, Priyanka Manchanda, Sunil K. Sharma

Journal Name: Current Topics in Medicinal Chemistry

Volume 14 , Issue 22 , 2014


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Abstract:

Chromones (1-benzopyran-4-ones) are natural occurring compounds present in representative amounts in a normal human diet and are associated with interesting physiological activities such as antiinflammatory, antidiabetic, antitumor, anticancer etc. These biological activities are thought to be related to the antioxidant properties of chromones i.e. to neutralize active oxygen and to cut off free radicals processes that can delay or inhibit cell impairment which leads to various diseases. In this review, we have summarized the literature reports published in about 70 research articles during the period January 2004 to March 2014 on more than 400 naturally as well as the synthetically derived chromone derivatives having antioxidant potential. The literature reports suggest that the double bond, a carbonyl group of chromone and 3´,4´-dihydroxy group (catechol) in ring B along with the C-3 and C-5 hydroxyl groups are important for radical scavenging activity. In turn, a decrease in the radical scavenging potential has been observed upon methylation / glycosylation of the hydroxyl groups on chromone nucleus.

Keywords: Antioxidants, Chromones, Flavones, MAO-inhibitors, Radical scavenging activity, Structure-activity relationship.

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Article Details

VOLUME: 14
ISSUE: 22
Year: 2014
Published on: 29 December, 2014
Page: [2552 - 2575]
Pages: 24
DOI: 10.2174/1568026614666141203141317
Price: $65

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